The study may also have found a link between atherosclerosis and cholesterol
Chinese scientists have developed an advanced non-invasive monitoring method cholesterol in the blood levels in humans. The innovative technology uses images of the skin on the hands and may eliminate the need for both hands venipuncture And fasting for a cholesterol test. Given the large amounts of cholesterol testing that clinical laboratories currently perform, this new technology could have a significant impact on cholesterol testing if further studies confirm its capabilities.
Notably, Chinese researchers have already developed a laboratory analyzer to perform the procedure and it is used in clinical care. However, in the United States and other countries, this technology will require additional clinical studies and regulatory review before clinical laboratories can use it in everyday patient care.
Cholesterol sensing system consists of detection detector associated with fluorescent group Which is related to skin cholesterol, and a detector. Cholesterol levels can be easily obtained from the skin, according to the researchers, by analyzing the way the skin absorbs and scatters light through a scanner.
If this technology is validated for clinical care, it may replace other clinical laboratory tests to measure cholesterol.
The scientists published their results in the journal Fats in health and diseaseentitled “Non-invasive skin cholesterol testing: a potential proxy for serum LDL-C and ApoB لقياس measurements. “
The above series of images are from researchers. Fats in health and disease A published study showing how to perform a non-invasive clinical laboratory test for total blood cholesterol. Patients always prefer non-invasive clinical laboratory tests to monitor blood biomarkers over venous punctures and fasting. (Copyright: Hefei Institutes of Physical Sciences, Chinese Academy of Sciences.)
The first evidence of the relationship between cholesterol and atherosclerosis
“Just put your hands in, and the system will tell you the cholesterol data,” Yikun Wang, PhDProfessor in the Department of Physical Sciences Hefei Institutes of Physical Sciences, Chinese Academy of SciencesResearch Team Leader Diagnostic world. “Cholesterol is one of several types of lipids (fats) that play an important role in the human body, we can keep track of your fat in this simple way.”
To perform the test, doctors first clean the test site on the fleshy edge of the palm with an alcohol swab. The patient’s non-dominant hand is used for testing because the skin on that hand is usually less abrasive and contains fewer melanocytes, allowing for more stable results. A plastic-coated ring is then placed over the test site and the examined portion is placed over the measuring hole in the detection system to measure the backlight spectrum of the skin.
Once the background signal is confirmed, the detection reagent is added to the loop until it is full. After 60 seconds, any excess of the detection reagent is removed from the loop. Then the cleaning reagent is added to the loop for 30 seconds and removed with a sterile cotton swab. Then the treated part of the skin is placed over the measuring hole in the detection system and two spectra The light is compared to measure cholesterol in the skin, which accurately correlates with cholesterol in the bloodstream.
“Compared to On site The finding used in previous clinical research, our device may provide more accurate results because we can avoid the effect of pressure and skin background differences [person to person]Wang said. The results of the study provide the first evidence of a relationship between cholesterol in the skin and Atherosclerosis disease in the Chinese, which may be of great interest to researchers around the world.”
Initially, 154 patients were diagnosed acute coronary syndrome (ACS) between January 2020 and April 2021 in the study. However, only 121 of these patients were included in the final study with the remainder excluded due to at least one of the following criteria:
- Date statins Take drugs,
- intolerance to statins,
- severe hepatic (liver) or renal (kidney) insufficiency, and
Your doctor’s use can affect the accuracy of the test
It was developed by researchers from Hefei Institutes of Chinese Academy of Physical Sciences, and University of Science and Technology of ChinaThe researchers noted that the way doctors operate the device could have an impact on the accuracy of test results.
‘A decisive step in [testing] The process that undergoes actuator change is blotting, which requires the operator to remove an unbound reagent from the palm before adding the indicator,” said Wang. Diagnostic world. “Excessive indicator solution can falsely increase skin cholesterol levels. Given this, we plan to develop a simplified and standardized scanning procedure.”
Millions of people in the United States suffer from a disease that requires regular blood cholesterol monitoring. Normal total cholesterol should be less than 200 milligrams per deciliter (mg/dL). According to the federal Centers for Disease Control and Prevention (CDC), approximately 94 million adults in the United States over the age of 20 have total cholesterol levels above 200 mg/dL and 28 million adults have total cholesterol levels above 240 mg/dL. In addition, 7% of children and adolescents between the ages of 6 and 19 have high cholesterol. For these reasons, cholesterol testing is a large part of the clinical laboratory tests that are performed daily in this country.
This new, non-invasive technology for monitoring total blood cholesterol in humans could greatly benefit patients, especially if it eliminates the need for venipuncture and fasting before the test. Clinical laboratory managers and pathologists may want to follow the progress of this new cholesterol testing technology as it demonstrates its value in China and is submitted for regulatory review in that country.