Fish oil supplement fails to reduce hip fractures

Austin, Texas – Researchers here report that omega-3 fatty acid supplementation failed to protect healthy middle-aged and older individuals from hip and other vertebral fractures.

Of the VITAL participants who were included in the omega-3 fatty acid portion of the study, there were 692 nonvertebral fractures among 12,933 people who took marine omega-3 supplements and 671 nonvertebral fractures in 12,938 people recruited. to the placebo group (HR 1.03, 95% CI 0.92-1.13), reported Meryl LeBeouf, MD, of Brigham and Women’s Hospital and Harvard Medical School in Boston.

In her oral presentation at the annual meeting of the American Society for Bone and Mineral ResearchLeBoff also reported no difference in hip fractures after 5.3 years of follow-up (51 with supplementation versus 55 with placebo, s= 0.60).

The same is true for major osteoporotic fractures and wrist fractures (s= 0.77 and q =0.25, respectively). Multiple fractures occurred in some participants, but the study did not include fractures of the fingers, toes, skull, facial bones or prostheses, and pathological fractures.

Another piece of agent experiment recently showed that Supplemental Vitamin D3 Compared to a placebo it did not reduce middle-aged fractures in older adults either.

“There is a high prevalence of osteoporotic fractures among the elderly,” LeBeouf noted, adding that “about 22% of U.S. adults aged 60 or older take supplemental omega-3 fatty acids. Although observational studies indicate that An inverse relationship between intakes of omega-3 fatty acids and fracture risk, a recent randomized controlled trial found no effect of omega-3 fatty acid supplementation on non-vertebral fractures.

In conducting the study, LeBeouf and colleagues randomly assigned 6,547 people to receive 1 gram per day of omega-3 fatty acids, and assigned 6,538 individuals to receive a placebo. The average age of the participants was 67 years. About half of the people in the study were women. About 71% were non-Hispanic whites. About 20% are black. The average BMI was 28. About 10% of the participants had a history of fractures or asthenia. About 27% have experienced a decline in the past 12 months.

Participants were asked to discontinue use of omega-3 supplements and to limit the intake of non-study vitamin D supplements to 800 IU or less per day and to limit calcium supplements to 1,200 mg/day or less. Fractures were reported annually by questionnaires or telephone calls. Accident fractures were separated centrally.

LeBeouf reported that after one year of follow-up, those individuals who were tested on a serum omega-3 fatty acid showed a 54.7% increase if they were given the supplement dose, but the placebo group increased by less than 2%. It reported that adherence to study tablets was 87% at 2 years and 85.7% at 5 years.

Commenting on the study, moderator Rodrigo Valderrapano, MD, a physician at Harvard Medical School and Brigham and Women’s Hospital, noted “a number of questions raised in the study that require further investigation.”

The study indicated that intake of omega-3 fatty acids may be problematic for men and for people with a lower BMI but may benefit those with a higher BMI, Valderrapano said. MedPage today. But he noted that it would have been difficult to fully understand these findings without further research.

“At this point, there does not appear to be an advantage of using omega-3 fatty acid supplements to prevent fractures in this population,” he said. He suggested that there might be other groups that could benefit, but that more research would be needed to determine what that population would be. Valderrapano was not involved in the biostudy.

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    Ed Sussman Freelance medical writer based in Fort Pierce, Florida, USA.

Disclosures

LeBoff has not disclosed any ties to the industry. Co-authors have reported relationships with Pharmavite and Pronova BioPharma.

Valderrabano has not disclosed any ties to the industry.

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