Oncology | Association between tumor matt

Figure 2

image: Figure 2: Gene-adjusted progression-free survival risk ratios examined.
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Credit: 2022 Dullea et al.

“Although meningioma patients often see positive tumor results, many tumors still recur after surgery.”

BUFFALO, NY – January 17, 2023 – A new research paper has been published in Oncology (Volume 9) on December 9, 2022, entitled “Association between tumor mutations and meningioma recurrence in grade I/II disease. “

Meningiomas are common intracranial tumors with a variable prognosis that is not fully captured by commonly used classification schemes. In this new study, researchers Jonathan T. Cibra, Melissa Amphlett, And Raj K. Shrivastava from Icahn School of Medicine at Mount Sinai And Sima 4 (The Mount Sinai Project) sought to determine the association between meningioma mutations and neoplastic outcomes using a targeted next-generation sequencing panel.

“As such, further characterization of the mechanisms of meningioma disease is needed in the pursuit of better prognosis and new targets for improved treatment models.”

The team identified 184 grade I and II meningiomas with more than 90 days of follow-up after surgery and linked targeted next-generation sequencing. For transgenes in more than 5% of the sample, Cox regression models for progression-free survival were calculated stratified by gene. They then built a multigene model by including all gene predictions with a s-value less than 0.20. Starting with this model, the researchers performed a retrospective selection to identify the most predictive factors.

ATM (HR = 4.448; 95% CI: 1.517–13.046), CREBBP (HR = 2.727; 95% confidence interval = 1.163–6.396), and column (HR = 0.544; HR = 0.311–0.952) was significantly associated with changes in disease progression after adjusting for clinical and pathologic factors. In the multiple gene model, only POLE remained a significant predictor of recurrence after adjusting for the same clinical variables. Reverse selection determined recurrence status and extent of resection and mutations ATM (HR = 7.333; 95% confidence interval = 2.318 – 23.195) and column (HR = 0.413; 95% CI = 0.229–0.743) as a predictor of recurrence.

Mutations in ATM and CREBBP have been associated with accelerated meningioma recurrence, and mutations in POLE were protective against recurrence. Each mutation has potential implications for treatment. The impact of these mutations on neoplastic outcome and as potential targets for intervention warrants future study.”

DOI: https://doi.org/10.18632/oncoscience.570

Correspondence to: Jonathan T. e-mail: jonathan.dullea@icahn.mssm.edu

Key words: Meningioma, Molecular Genome, Pole, ATM, CREBBP

About Oncology:

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